Drug Profile


Alternative Names: Cancer vaccine heat shock protein peptide complex-96 - Agenus; Cancer vaccine HSPPC-96; G-100; G-200; Heat shock protein peptide complex 96 cancer vaccine - Agenus; Heat-shock protein-based vaccine; HSPPC-96; NP-150; Oncophage; Prophage series G-100 vaccine; Prophage series G-200 vaccine; Prophage™ heat shock protein-based autologous vaccine

Latest Information Update: 23 Jan 2017

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At a glance

  • Originator Fordham University; Mount Sinai School of Medicine
  • Developer Agenus; University of Texas Health Science Center at Houston
  • Class Antineoplastics; Cancer vaccines; Heat shock proteins
  • Mechanism of Action Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma; Malignant melanoma; Renal cell carcinoma
  • New Molecular Entity No
  • Available For Licensing Yes - Cancer

Highest Development Phases

  • Marketed Renal cell carcinoma
  • Phase II Glioma; Malignant melanoma
  • Preclinical Brain cancer
  • No development reported Colorectal cancer; Gastric cancer; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Pancreatic cancer
  • Discontinued Chronic myeloid leukaemia; Leukaemia; Sarcoma

Most Recent Events

  • 17 Jan 2017 Agenus and National Cancer Institute plan a phase II trial of vitespen and pembrolizumab for Glioma (Combination therapy, Newly diagnosed) in USA
  • 08 Feb 2016 The University of Texas Health Science Center and Agenus withdraw a phase I/II trial for Malignant melanoma (Combination therapy, Late-stage disease) in USA (NCT02452281)
  • 04 Jun 2015 Vitespen is still in phase II trials for Glioma (Recurrent & Newly diagnosed, Combination therapy) in USA
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