Drug Profile


Alternative Names: PA 824

Latest Information Update: 03 Jul 2017

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At a glance

  • Originator Novartis
  • Developer Global Alliance for TB Drug Development
  • Class 2 ring heterocyclic compounds; Antituberculars; Nitroimidazoles; Oxazines; Phenyl ethers; Small molecules
  • Mechanism of Action Cell wall inhibitors; Nitric oxide stimulants; Protein synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Tuberculosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Tuberculosis

Most Recent Events

  • 03 Jul 2017 Discontinued - Phase-I for Tuberculosis (Monotherapy, In volunteers) in USA (PO)
  • 27 Mar 2017 Global Alliance for TB Drug Development plans a phase III trial for Tuberculosis (Combination therapy) (NCT03086486)
  • 01 Jan 2017 Phase-II/III clinical trials in Tuberculosis (Combination therapy) in Uzbekistan (PO) (NCT02589782)
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