Fms-like tyrosine kinase 3 ligand - Celldex Therapeutics

Drug Profile

Fms-like tyrosine kinase 3 ligand - Celldex Therapeutics

Alternative Names: CDX-301; Flt-3 ligand; Flt3-L; Mobista; rhuFlt3L

Latest Information Update: 09 Oct 2017

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At a glance

  • Originator Amgen
  • Developer Amgen; Celldex Therapeutics Inc; Icahn School of Medicine at Mount Sinai; National Cancer Institute (USA)
  • Class Adjuvants; Antineoplastics; Cytokines; Recombinant proteins
  • Mechanism of Action Dendritic cell stimulants; Fms-like tyrosine kinase 3 stimulants; Haematopoiesis stimulants; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Malignant melanoma
  • Phase I/II B cell lymphoma
  • Discontinued Autoimmune disorders; Infections; Non-Hodgkin's lymphoma; Solid tumours; Stem cell mobilisation

Most Recent Events

  • 03 Dec 2016 Preclinical data presented at the 58th Annual Meeting and Exposition of the American Society of Haematology
  • 08 Aug 2016 Fms-like tyrosine kinase 3 ligand is still in phase-I/II trials for B-cell lymphoma (Combination therapy, Low-grade disease) in USA (Intratumoural) (NCT01976585),
  • 05 May 2016 Discontinued - Phase-II for Stem cell mobilisation in USA (Parenteral) because Celldex is prioritising its resourses
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