Drug Profile


Alternative Names: A 147627; A-1476271; Abbott 147627; ABT-147627; ABT-627; Atrasentan hydrochloride; Xinlay

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Abbott Laboratories
  • Developer Abbott Laboratories; AbbVie
  • Class Amides; Antineoplastics; Benzodioxoles; Carboxylic acids; Pyrrolidines; Small molecules
  • Mechanism of Action Endothelin A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Diabetic nephropathies
  • Discontinued Brain cancer; Coronary artery restenosis; Heart failure; Lung cancer; Ovarian cancer; Prostate cancer; Renal cancer

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 28 Sep 2016 Efficacy data from the phase II S0421 trial in Prostate cancer presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
  • 13 Aug 2015 Phase-II was completed for Diabetic nephropathies in Japan and Puerto Rico
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