Drug Profile


Alternative Names: Aerosolized KL4 surfactant; Aerosurf; ATI-01; ATI-02; DSC-104; DSC-105; KL-4 lung surfactant; KL4 pulmonary surfactant; KL4 surfactant; Lucinactant; Surfaxin; Surfaxin LS

Latest Information Update: 24 Feb 2017

Price : $50

At a glance

  • Originator The Scripps Research Institute
  • Developer Discovery Laboratories; University of Pennsylvania; Windtree Therapeutics
  • Class Amino acids; Peptides; Surfactants
  • Mechanism of Action Cell membrane permeability enhancers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Bronchopulmonary dysplasia; Neonatal respiratory distress syndrome; Acute lung injury; Adult respiratory distress syndrome; Meconium aspiration syndrome; Cystic fibrosis
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Neonatal respiratory distress syndrome
  • Preclinical Acute lung injury; Chronic obstructive pulmonary disease; Lung disorders; Reperfusion injury
  • No development reported Adult respiratory distress syndrome; Bronchopulmonary dysplasia; Cystic fibrosis
  • Discontinued Asthma; Meconium aspiration syndrome; Otitis media; Respiratory insufficiency; Rhinitis; Sinusitis

Most Recent Events

  • 16 Feb 2017 Pharmacodynamics data from a preclinical trial in Lung injury released by WindTree Therapeutics
  • 03 Nov 2016 Pharmacodynamics data from a preclinical trial in Lung disorders released by WindTree Therapeutics
  • 24 Oct 2016 Preclinical pharmacodynamics data from a Lung deposition study in non-human primates released by WindTree Therapeutics
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