Drug Profile


Alternative Names: AMD 473; JM 473; NX 473; ZD 0473

Latest Information Update: 22 Jan 2013

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At a glance

  • Originator Johnson Matthey
  • Developer Poniard Pharmaceuticals
  • Class Antineoplastics; Platinum complexes; Small molecules
  • Mechanism of Action DNA cross linking agents; DNA synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Small cell lung cancer
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Colorectal cancer; Ovarian cancer; Prostate cancer; Small cell lung cancer; Solid tumours

Most Recent Events

  • 30 Mar 2012 Discontinued - Phase-I for Solid tumours in USA (PO)
  • 30 Mar 2012 Discontinued - Phase-II for Colorectal cancer (combination therapy, first-line therapy, metastatic disease) in Russia (IV)
  • 30 Mar 2012 Discontinued - Phase-II for Ovarian cancer (second-line therapy) in Europe (IV)
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