Antithrombin alfa

Drug Profile

Antithrombin alfa

Alternative Names: Antithrombin III recombinant human; Antithrombin III transgenic; ATryn; Recombinant human antithrombin III; rhATIII; Transgenic antithrombin III

Latest Information Update: 12 Nov 2016

Price : $50

At a glance

  • Originator GTC Biotherapeutics
  • Developer GTC Biotherapeutics; Knight Therapeutics; LEO Pharma; rEVO Biologics
  • Class Alpha globulins; Anticoagulants; Antithrombins; Antithrombotics; Recombinant proteins
  • Mechanism of Action Thrombin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Antithrombin III deficiency; Blood coagulation disorders
  • New Molecular Entity Yes
  • Available For Licensing Yes - Antithrombin III deficiency; Blood coagulation disorders

Highest Development Phases

  • Marketed Antithrombin III deficiency
  • Phase III Blood coagulation disorders; Preeclampsia
  • Discontinued Acute lung injury; Burns; Disseminated intravascular coagulation; Solid tumours

Most Recent Events

  • 25 Apr 2016 Knight Therapeutics receives Notice of Deficiency from the Health Canada for antithrombin alfa in Antithrombin III deficiency
  • 06 Aug 2015 Preregistration for Antithrombin III deficiency in Canada (IV)
  • 02 Sep 2014 Antithrombin alfa sublicensed to Knight Therapeutics in Canada; rights previously licensed to Orphan Canada
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