Drug Profile


Alternative Names: EMD 128130

Latest Information Update: 31 May 2017

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At a glance

  • Originator Merck KGaA
  • Developer Merck KGaA; Newron Pharmaceuticals
  • Class Antiparkinsonians; Antipsychotics
  • Mechanism of Action Dopamine D2 receptor partial agonists; Serotonin 1A receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Rett syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Rett syndrome
  • Discontinued Drug-induced dyskinesia

Most Recent Events

  • 24 Oct 2016 Phase-II/III clinical trials in Rett syndrome in Italy (PO)
  • 21 Jul 2016 Phase-II/III clinical trials in Rett syndrome in USA (PO)
  • 13 Jun 2016 Newron Pharmaceuticals plans the phase II/III STARS trial in Rett syndrome in USA, India and Italy (NCT02790034)
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