Drug Profile


Alternative Names: Cilcane; EMD-121974; EMD-85189; ICE1

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator Merck KGaA; The Scripps Research Institute; University of Munich
  • Developer Iceni Pharmaceuticals; Martin Luther University of Halle-Wittenberg; Merck KGaA; National Cancer Institute (USA)
  • Class Antineoplastics; Cyclic peptides; Small molecules; Venoms
  • Mechanism of Action Angiogenesis inhibitors; Integrin alphaVbeta3 antagonists; Integrin alphaVbeta5 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Multiple myeloma
  • Discontinued Glioblastoma; Head and neck cancer; Lymphoma; Non-small cell lung cancer; Prostate cancer; Solid tumours

Most Recent Events

  • 25 May 2016 Preclinical trials in Multiple myeloma in United Kingdom (unspecified route)
  • 25 May 2016 Iceni Pharmaceuticals plans a phase II trial for Multiple myeloma (Combination therapy, Late-stage disease)
  • 01 Aug 2013 Merck completes the phase III CENTRIC trial in Glioblastoma (Combination therapy, Newly diagnosed) in US, Belgium, Austria, Germany, France, Spain, Italy, Slovakia, Hungary, Czech Republic, Netherlands, India, and the UK (NCT00689221)
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