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Varespladib - Ophirex

Drug Profile

Varespladib - Ophirex

Alternative Names: A-001; A-002; LY-315920; LY-333013; Methyl-varespladib; S-3013; S-5920; Varespladib methyl

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Eli Lilly and Company; Shionogi
  • Developer Anthera Pharmaceuticals; Ophirex; University Health Network
  • Class Acetic acids; Anti-inflammatories; Antirheumatics; Indoles; Small molecules
  • Mechanism of Action Phospholipase A2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute lung injury
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II COVID 2019 infections; Snake venom poisoning
  • Discontinued Acute coronary syndromes; Acute lung injury; Coronary artery disease; Multiple organ failure; Systemic inflammatory response syndrome

Most Recent Events

  • 10 Jan 2023 Varespladib receives Fast track status from the US FDA for Snake venom poisoning
  • 05 Jan 2023 Ophirex completes enrolment in the phase II BRAVO trial for Snake venom poisoning in India and US (NCT04996264)
  • 22 Nov 2022 Ophirex terminates the phase II STAIRS clinical trial in COVID-2019 infections in USA, due to slow enrollment resulting from decrease in infection rate (PO) (NCT04969991)
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