Aprepitant

Drug Profile

Aprepitant

Alternative Names: Emend; L-754030; MK-0869; MK-869; ONO-7436

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Merck & Co
  • Developer Fudan University Shanghai Cancer Center; Hunan Province Tumor Hospital; Merck & Co; Ono Pharmaceutical
  • Class Antidepressants; Antiemetics; Fluorobenzenes; Morpholines; Small molecules; Triazoles
  • Mechanism of Action Neurokinin 1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chemotherapy-induced nausea and vomiting; Postoperative nausea and vomiting
  • Discontinued Anxiety disorders; Major depressive disorder; Schizophrenia

Most Recent Events

  • 21 Apr 2017 Duke University Medical Center and Merck completes a phase II trial in Chemotherapy induced nausea and vomiting (Prevention, Combination therapy) in USA (PO) (NCT01450826)
  • 01 Sep 2016 Merck completes a phase II trial in Postoperative nausea and vomiting (Prevention, In adolescents, In children, In infants, In neonates) in USA, Hungary, Spain, Italy and Czech Republic (NCT01732458/EudraCT2011-006006-27)
  • 17 Apr 2016 Biomarkers information updated
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