Zoptarelin doxorubicin

Drug Profile

Zoptarelin doxorubicin

Alternative Names: AEZS-108; AN-152; D-81858; Doxorubicin-GnRH agonist conjugate; ZEN-008

Latest Information Update: 15 Feb 2017

Price : $50

At a glance

  • Originator Tulane University
  • Developer AEterna Zentaris Inc; National Cancer Institute (USA); University of Southern California
  • Class Anthracyclines; Cytostatic antibiotics; Doxorubicins; Drug conjugates
  • Mechanism of Action DNA intercalators; Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity No
  • Available For Licensing Yes - Endometrial cancer

Highest Development Phases

  • Phase III Endometrial cancer
  • Phase II Breast cancer; Ovarian cancer
  • Phase I/II Prostate cancer
  • Discontinued Urogenital cancer

Most Recent Events

  • 02 Feb 2017 University of Southern California and AEterna Zentaris completes phase I/II trial in Prostate cancer (Hormone refractory, Metastatic disease, Second-line therapy or greater) in USA (NCT01240629)
  • 02 Feb 2017 AEterna Zentaris completes a phase III trial in Endometrial cancer (Second-line therapy or greater, Late-stage disease, Metastatic disease) in USA, Austria, Belarus, Belgium, Bosnia and Herzegovina, Bulgaria, Canada, Czech Republic, Denmark, Finland, Germany, Ireland, Israel, Italy, Netherlands, Norway, Poland, Romania, Russia, Spain, Ukraine, United Kingdom (NCT01767155)
  • 12 Oct 2016 Zoptarelin doxorubicin sub-licensed to Specialised Therapeutics Asia in Australia and New Zealand
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