Drug Profile


Alternative Names: anti-VEGF aptamer; BLO 021; EYE-001; Macugen; NX-1838; Pegaptanib octasodium; Pegaptanib sodium

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Gilead Sciences
  • Developer Eyetech Inc.; Gilead Sciences; Pfizer; Valeant Pharmaceuticals International
  • Class Eye disorder therapies; Nucleotide aptamers
  • Mechanism of Action Angiogenesis inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Age-related macular degeneration
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Age-related macular degeneration
  • No development reported Diabetic macular oedema; Diabetic retinopathy
  • Discontinued Choroidal neovascularisation; Retinal vascular occlusion

Most Recent Events

  • 18 Dec 2015 Isis Pharmaceuticals is now called Ionis Pharmaceuticals
  • 15 May 2014 No development reported - Phase-III for Diabetic retinopathy in USA (Intravitreous)
  • 04 Mar 2013 Discontinued - Phase-II for Retinal vascular occlusion in USA (Intravitreous)
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