Drug Profile


Alternative Names: Anti-CD4 monoclonal antibody HuMax-CD4™; Anti-CD4 monoclonal antibody MDX CD4; HuMax-CD4; MDX CD4; MDX-016

Latest Information Update: 09 Sep 2015

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At a glance

  • Originator Genmab
  • Developer Emergent BioSolutions; Genmab
  • Class Antirheumatics; Monoclonal antibodies
  • Mechanism of Action CD4 antigen inhibitors; Signal transduction pathway inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cutaneous T cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Cutaneous T cell lymphoma; Peripheral T-cell lymphoma; Psoriasis; Rheumatoid arthritis

Most Recent Events

  • 06 Jun 2011 Zanolimumab licensed to Emergent BioSolutions worldwide
  • 31 Dec 2010 Suspended - Phase-III for Cutaneous T-cell lymphoma in European Union (IV)
  • 31 Dec 2010 Suspended - Phase-III for Cutaneous T-cell lymphoma in USA (IV)
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