Drug Profile


Alternative Names: KRYSTEXXA; Methoxypolyethylene glycol uricase; PEG urate oxidase; PEG-uricase; PEGylated uricase; Polyethylene glycol-uricase; Puricase; Urate-oxidase-PEG

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Duke University; Mountain View Pharmaceuticals
  • Developer Savient Pharmaceuticals
  • Class Antigouts; Oxidoreductases; Polyethylene glycols; Recombinant proteins
  • Mechanism of Action Urate oxidase stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gout
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gout

Most Recent Events

  • 14 Jun 2017 Additional efficacy data from phase III trials in Gout released by Horizon Pharma
  • 11 May 2016 Horizon Pharma receives notice of allowance for a patent application related to pegloticase in USA
  • 11 May 2016 The US label for pegloticase carries a black box warning related to the risk of anaphylaxis and infusion reactions
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