Drug Profile


Alternative Names: DE-089; Diquafosol sodium; Diquafosol tetrasodium; Diquas; Diquas ophthalmic solution 3%; INS 365; INS 365 Ophthalmic; INS 365 Respiratory; KPY 998; Prolacria

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Inspire Pharmaceuticals
  • Developer Inspire Pharmaceuticals; Santen Pharmaceutical
  • Class Expectorants; Eye disorder therapies; Polyphosphates; Small molecules; Uracil nucleotides
  • Mechanism of Action Purinoceptor P2U agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Dry eyes
  • Discontinued Bronchitis; Chronic obstructive pulmonary disease; Corneal ulcer; Cystic fibrosis

Most Recent Events

  • 10 Jul 2017 Santen Pharmaceutical plans a phase I trial for Dry eyes in Taiwan in July 2017 (NCT03216096)
  • 08 Sep 2016 Santen Pharmaceutical initiates a clinical trial for Dry eyes in Japan (Ophthalmic) (UMIN000024064)
  • 01 Feb 2016 Launched for Dry eyes in Thailand and Vietnam (Topical) before February 2016 (Santen website, February 2016)
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