Drug Profile


Alternative Names: Aplidin; Aplidine; DDB; Dehydrodidemnin B

Latest Information Update: 06 Oct 2017

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At a glance

  • Originator PharmaMar
  • Class Antineoplastics; Depsipeptides
  • Mechanism of Action Apoptosis stimulants; Cell cycle inhibitors; Protein synthesis inhibitors; Vascular endothelial growth factor receptor-1 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma; Acute lymphoblastic leukaemia
  • New Molecular Entity Yes
  • Available For Licensing Yes - Multiple myeloma; Multiple myeloma; Peripheral T-cell lymphoma

Highest Development Phases

  • Preregistration Multiple myeloma
  • Phase II Non-Hodgkin's lymphoma; T cell lymphoma
  • Phase I Solid tumours
  • No development reported Liposarcoma; Malignant melanoma; Myelofibrosis
  • Discontinued Leukaemia; Prostate cancer

Most Recent Events

  • 04 Oct 2017 Preregistration for Multiple myeloma (Combination therapy, Second-line therapy or greater) in Switzerland (IV)
  • 09 Aug 2017 Clinical trials in Multiple myeloma (First-line therapy, Combination therapy) in Czech Republic (IV)
  • 09 Aug 2017 Clinical trials in Multiple myeloma (First-line therapy, Combination therapy) in Spain (IV)
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