Drug Profile


Alternative Names: BNP 1350; BNP Karenitecin; DB 172; Karenitecin; UNII-24R60NVC41

Latest Information Update: 02 Nov 2015

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At a glance

  • Originator BioNumerik Pharmaceuticals
  • Developer Alliance for Clinical Trials in Oncology; Baylor College of Medicine; BioNumerik Pharmaceuticals; Pediatric Brain Tumor Consortium
  • Class Antineoplastics; Camptothecins; Small molecules
  • Mechanism of Action DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase III Ovarian cancer
  • Phase II Brain cancer; Malignant melanoma; Non-small cell lung cancer
  • Phase I Solid tumours

Most Recent Events

  • 02 Sep 2015 BioNumerik is considering further development options for cositecan in Ovarian cancer (Mucinous disease, Late-stage disease)
  • 02 Sep 2015 BioNumerik is still developing the oral formulation of cositecan
  • 23 Mar 2012 BioNumerik Pharmaceuticals completes enrolment in its phase III trial for Ovarian cancer in Hungary, Lithuania, Poland, Romania and Russia (NCT00477282)
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