Drug Profile


Alternative Names: AMG-706; Motesanib diphosphate

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Amgen
  • Developer Amgen; Takeda Bio Development Center
  • Class Amides; Antineoplastics; Indoles; Nicotinic-acids; Pyridines; Small molecules
  • Mechanism of Action Platelet-derived growth factor receptor antagonists; Proto oncogene protein c ret inhibitors; Proto oncogene protein c-kit inhibitors; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Breast cancer; Colorectal cancer; Gastrointestinal stromal tumours; Non-small cell lung cancer; Thyroid cancer

Most Recent Events

  • 19 May 2015 Discontinued - Phase-III for Non-small cell lung cancer (Combination therapy, First-line therapy, Late-stage disease) in Taiwan, South Korea, Hong Kong, Japan (PO)
  • 17 Feb 2015 Takeda Pharmaceuticals terminates the MONET-A phase III trial in Non-small cell lung cancer (advanced disease, combination therapy) in Japan, South Korea, Taiwan, Hong Kong
  • 01 Dec 2012 Amgen completes a phase II trial in Gastrointestinal stromal tumours in Japan (NCT00254267)
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