Tipifarnib

Drug Profile

Tipifarnib

Alternative Names: R-115777; Zarnestra

Latest Information Update: 01 Mar 2017

Price : $50

At a glance

  • Originator Janssen L.P.; Janssen-Cilag; Johnson & Johnson
  • Developer Emory University; H. Lee Moffitt Cancer Center and Research Institute; Janssen-Cilag; Johnson & Johnson; Kura Oncology; National Cancer Institute (USA); Samsung Medical Center; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Quinolones; Small molecules
  • Mechanism of Action Apoptosis inhibitors; Apoptosis stimulants; Farnesyltranstransferase inhibitors; Ras protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Chronic myelomonocytic leukaemia; Head and neck cancer; Myelodysplastic syndromes; Peripheral T-cell lymphoma; Thyroid cancer; Urogenital cancer
  • Phase I/II Multiple myeloma
  • Discontinued Breast cancer; Glioblastoma; Pancreatic cancer

Most Recent Events

  • 01 Oct 2016 Phase-II clinical trials in Chronic myelomonocytic leukaemia in USA (PO) (NCT02807272)
  • 10 Aug 2016 Positive interim efficacy data from a phase II trial in Solid tumours (HRAS mutant) released by Kura Oncology
  • 20 Jun 2016 Kura Oncology plans a phase II trial in Chronic myelomonocytic leukaemia in USA (NCT02807272)
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