Drug Profile


Alternative Names: AZD-3480; RJR-1734; TC 01734; TC-1734; TC-1734-112

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator R. J. Reynolds Tobacco Company; Targacept
  • Developer AstraZeneca; Targacept
  • Class Amines; Neuroprotectants; Nootropics; Pyridines; Small molecules
  • Mechanism of Action Alpha4 beta2 nicotinic receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Alzheimer's disease; Attention-deficit hyperactivity disorder; Cognition disorders

Most Recent Events

  • 17 Apr 2016 Biomarkers information updated
  • 14 Jul 2014 Discontinued - Phase-II for Alzheimer's disease in USA, Czech Republic, Romania, Slovakia and Ukraine (PO)
  • 29 Apr 2013 Targacept completes enrolment in its phase IIb trial for Alzheimer’s disease in USA, Czech Republic, Romania, Slovakia & Ukraine
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