OCX 191

Drug Profile

OCX 191

Alternative Names: 3-AP; NSC 663249; NSC#663249; NTO-1151; OCX-0191; Triapine

Latest Information Update: 06 Oct 2017

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At a glance

  • Originator Yale University
  • Developer National Cancer Institute (USA); Ology Bioservices; Trethera; Vion Pharmaceuticals
  • Class Antineoplastics; Pyridines; Small molecules; Thiosemicarbazones
  • Mechanism of Action Ribonuclease inhibitors; Ribonucleotide reductase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cervical cancer; Gynaecological cancer; Solid tumours
  • Preclinical Leukaemia
  • No development reported Breast cancer; Cholangiocarcinoma; Gallbladder cancer; Haematological malignancies; Head and neck cancer; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer
  • Discontinued Cancer; Cancer metastases; Hepatitis B; Herpes simplex virus infections; HIV infections

Most Recent Events

  • 02 Oct 2017 Nanotherapeutics is now called Ology Bioservices
  • 05 Jan 2017 Preclinical trials in Leukaemia (Combination therapy) in USA (unspecified route)
  • 05 Jan 2017 Trethera plans a phase I trial in Leukaemia (Combination therapy)
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