Drug Profile


Alternative Names: 10-Propargyl-10-deazaaminopterin; Difolta; Folotyn; PDX; Pralatrexate injection

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator Memorial Sloan-Kettering Cancer Center; Southern Research Institute; SRI International
  • Developer Allos Therapeutics; Mundipharma International; Rafa Laboratories
  • Class Antineoplastics; Pterins; Small molecules
  • Mechanism of Action Antimetabolites; Tetrahydrofolate dehydrogenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - T cell lymphoma; Follicular lymphoma; Peripheral T-cell lymphoma; Diffuse large B cell lymphoma; Hodgkin's disease; Bladder cancer; Cutaneous T cell lymphoma
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Peripheral T-cell lymphoma
  • No development reported B cell lymphoma; Bladder cancer; Breast cancer; Cutaneous T cell lymphoma; Hodgkin's disease; Mesothelioma; Non-Hodgkin's lymphoma; Non-small cell lung cancer

Most Recent Events

  • 06 Dec 2016 Interim results from a phase I trial in Peripheral T-cell lymphoma reported at the 58th Annual Meeting and Exposition of the American Society of Hematology (ASH-Hem-2016)
  • 11 Jan 2016 Servier in-licenses pralatrexate (Folotyn®) from Spectrum Pharmaceuticals in Canada
  • 31 Oct 2015 Phase-I clinical trials in Peripheral T-cell lymphoma (Newly diagnosed, Combination therapy) in USA (IV)
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