Drug Profile


Alternative Names: VX-745

Latest Information Update: 30 Aug 2017

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At a glance

  • Originator Vertex Pharmaceuticals
  • Developer EIP Pharma; Vertex Pharmaceuticals
  • Class Anti-inflammatories; Antidementias; Pyridazines; Small molecules
  • Mechanism of Action P38 mitogen-activated protein kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease
  • Discontinued Asthma; Crohn's disease; Rheumatoid arthritis; Stroke

Most Recent Events

  • 16 Aug 2017 Neflamapimod is still at phase II development stage for Alzheimer's disease in USA and Netherlands (EIP Pharma website, August 2017)
  • 16 Jul 2017 Interim pharmacokinetics-pharmacodynamics data from a phase IIa trial in Alzheimer's disease presented at the Alzheimer's Association International Conference 2017 (AAIC-2017)
  • 16 Dec 2016 Biomarkers information updated
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