Imetelstat - Janssen Biotech

Drug Profile

Imetelstat - Janssen Biotech

Alternative Names: GRN 140719; GRN 163; GRN 163-L; GRN 719; GRN163L peptide; Imetelstat sodium; JNJ-63935937

Latest Information Update: 02 Nov 2017

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At a glance

  • Originator Geron Corporation
  • Developer Geron Corporation; Janssen Biotech
  • Class Antineoplastics; Oligonucleotides; Oligopeptides
  • Mechanism of Action Telomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelofibrosis; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Myelodysplastic syndromes
  • Phase II Myelofibrosis
  • Preclinical Acute myeloid leukaemia; Chronic myeloid leukaemia
  • Suspended Multiple myeloma
  • Discontinued Breast cancer; Essential thrombocythaemia; Lymphoproliferative disorders; Non-small cell lung cancer; Polycythaemia vera; Solid tumours

Most Recent Events

  • 31 Oct 2017 Imetelstat receives Fast Track designation for Myelodysplastic syndromes [IV] (Second-line therapy or greater) in USA
  • 31 Jul 2017 Interim efficacy and adverse events data from Part 1 of the phase II/III IMerge trial in Myelodysplastic syndromes released by Geron Corporation
  • 01 Apr 2017 Adverse events and pharmacodynamics data from a preclinical study in Acute myeloid leukaemia presented at the 108th Annual Meeting of the American Association for Cancer Research (AACR-2017)
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