Drug Profile


Alternative Names: CB-500,929; DX-88; EPI-KAL2; FOV 2302; Kalbitor

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Dyax
  • Developer Cubist Pharmaceuticals; Dyax; Fovea Pharmaceuticals; Neopharm Ltd; Shire
  • Class Analgesics; Anti-inflammatories; Peptides; Recombinant proteins
  • Mechanism of Action Plasma-kallikrein-inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hereditary angioedema
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hereditary angioedema
  • Suspended Retinal oedema
  • Discontinued Angioedema; Surgical blood loss

Most Recent Events

  • 22 Jan 2016 Dyax has been acquired by and merged into Shire
  • 21 Jan 2015 Cubist Pharmaceuticals has been acquired by Merck & Co
  • 01 Jun 2014 CMIC terminates its licence for ecallantide in Japan (Dyax 10-K, February 2015)
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