Drug Profile


Alternative Names: CS-682; CYC-682

Latest Information Update: 03 Apr 2017

Price : $50

At a glance

  • Originator Daiichi Sankyo Company; Hokkaido University; Kanazawa University
  • Developer Cyclacel Pharmaceuticals; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Arabinonucleosides; Small molecules
  • Mechanism of Action Antimetabolites; DNA-directed DNA polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelodysplastic syndromes; Acute myeloid leukaemia
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Chronic lymphocytic leukaemia; Myelodysplastic syndromes; Non-small cell lung cancer
  • Phase I/II Solid tumours
  • Preclinical Ovarian cancer
  • Discontinued Cutaneous T cell lymphoma

Most Recent Events

  • 28 Mar 2017 Cyclacel Pharmaceuticals completes the phase III SEAMLESS trial in Acute myeloid leukaemia (First-line therapy, In the elderly, Newly diagnosed) in Austria, Belgium, France, Germany, hungary, Ireland, Italy, Poland, Spain, Sweden, United Kingdom and USA
  • 23 Feb 2017 Interim efficacy and adverse events data from the phase III SEAMLESS trial in Acute myeloid leukaemia (In the elderly) where the priamry endpoint was not met was released by Cyclacel
  • 03 Dec 2016 Leukaemia and Lymphoma Research Institute and National Cancer Research Institute terminates the AML-LI-1 trial in Acute myeloid leukaemia (Combination therapy, First line therapy) in United Kingdom and Denmark
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