Drug Profile


Alternative Names: ABR-215062; Laquinimod sodium; Nerventra; SAIK-MS; TV-5600

Latest Information Update: 02 Oct 2017

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At a glance

  • Originator Active Biotech
  • Developer Icahn School of Medicine at Mount Sinai; National University of Singapore; Ruhr-University Bochum; Tel Aviv University; Teva Pharmaceutical Industries; University College London; University of British Columbia
  • Class Quinolones; Small molecules
  • Mechanism of Action Aryl hydrocarbon receptor agonists; Brain-derived neurotrophic factor expression stimulants; Immunomodulators; Neuron stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Huntington's disease
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Multiple sclerosis
  • Phase II Crohn's disease; Huntington's disease
  • No development reported Lupus nephritis
  • Discontinued Systemic lupus erythematosus

Most Recent Events

  • 13 Sep 2017 Teva Pharmaceutical Industries terminates a phase III trial for Multiple Sclerosis in several countries including USA and EU as the sponsor terminated the RRMS studies (PO) (NCT00988052)
  • 13 Sep 2017 Teva Pharmaceuticals terminates a phase III extension trial for Multiple sclerosis (Relapsing-remitting) in Estonia, Italy, Spain, Czech Republic, Slovakia, Poland, Bulgaria, Germany, Spain, Ukraine, USA, Croatia, Georgia, Israel, Lithuania, Macedonia, Romania, Russia and South Africa as the sponsor terminated the RRMS studies (PO) (NCT01047319)
  • 19 Apr 2017 Teva Pharmaceutical completes the phase III CONCERTO trial for Multiple sclerosis in US, Canada, Albania, Bosnia-Herzegovina, Croatia, Latvia, Macedonia, Moldova, Montenegro, Serbia, the UK, Chile, Mexico, Puerto Rico, Belarus, Georgia, Israel, Kazakhstan, Russia, South Africa, South Korea, Ukraine, Austria, Bulgaria, Czech Republic, Estonia, France, Germany, Greece, Hungary, Italy, Poland, Romania, Slovakia, Belgium, Latvia, Poland and Spain(NCT01707992)
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