Laquinimod - Teva Pharmaceutical Industries

Drug Profile

Laquinimod - Teva Pharmaceutical Industries

Alternative Names: ABR-215062; Laquinimod sodium; Nerventra; SAIK-MS; TV-5600

Latest Information Update: 05 Dec 2017

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At a glance

  • Originator Active Biotech
  • Developer Icahn School of Medicine at Mount Sinai; National University of Singapore; Ruhr-University Bochum; Tel Aviv University; Teva Pharmaceutical Industries; University College London; University of British Columbia
  • Class Anti-inflammatories; Neuropsychotherapeutics; Quinolones; Small molecules
  • Mechanism of Action Aryl hydrocarbon receptor agonists; Brain-derived neurotrophic factor expression stimulants; Immunomodulators; Neuron stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Huntington's disease
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Multiple sclerosis
  • Phase II Crohn's disease; Huntington's disease
  • No development reported Lupus nephritis
  • Discontinued Systemic lupus erythematosus

Most Recent Events

  • 01 Dec 2017 Efficacy and adverse event data from the phase II ARPEGGIO trial in Multiple sclerosis, which did not meet its primary endpoint, released by Active Biotech (NCT02284568)
  • 04 Nov 2017 No recent reports of development identified for preclinical development in Huntington's-disease in Israel (PO, Capsule)
  • 09 Oct 2017 Teva Pharmaceutical terminates a phase II trial in Multiple sclerosis in Czech, Germany, Hungary, Israel, Italy, Poland, Russia, Spain and United Kingdom as sufficient long term clinical data was collected for the study drug in the relevant dose (NCT00745615)
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