Sorafenib

Drug Profile

Sorafenib

Alternative Names: BAY 43-9006 Tosylate; BAY 54-9085; BAY-43-9006; Nexavar; Sorafenib tosilate; Sorafenib tosylate

Latest Information Update: 09 Jan 2017

Price : $50

At a glance

  • Originator Onyx Pharmaceuticals; University of Kentucky
  • Developer ACORN Research; Asan Medical Center; Bayer; Beth Israel Deaconess Medical Center; Charite of Berlin; Indiana University School of Medicine; National Cancer Center (Korea); National Cancer Institute (USA); Onyx Pharmaceuticals; Oregon Health & Science University; Thomas Jefferson University; University of California, San Diego; University of Texas M. D. Anderson Cancer Center; Yale University
  • Class Amides; Antineoplastics; Benzenesulfonates; Chlorobenzenes; Pyridines; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Fms-like tyrosine kinase 3 inhibitors; Mitogen-activated protein kinase inhibitors; Mitogen-activated protein kinase kinase inhibitors; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein b raf inhibitors; Proto oncogene protein c ret inhibitors; Proto oncogene protein c-kit inhibitors; Proto oncogene proteins c raf inhibitors; Raf kinase inhibitors; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer; Renal cell carcinoma; Thyroid cancer
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hepatocellular carcinoma; Renal cell carcinoma; Thyroid cancer
  • Phase II Acute myeloid leukaemia; Breast cancer; Chronic lymphocytic leukaemia; Gastric cancer; Glioma; Head and neck cancer; Myelodysplastic syndromes; Neurofibromatoses; Ovarian cancer; Portal hypertension; Soft tissue sarcoma
  • Phase I Acute promyelocytic leukaemia; Cancer; Neuroendocrine tumours; Pancreatic cancer
  • Suspended Malignant melanoma; Prostate cancer
  • No development reported Colorectal cancer; Germ cell and embryonal neoplasms
  • Discontinued Non-small cell lung cancer; Small cell lung cancer

Most Recent Events

  • 30 Dec 2016 NICE recommends sorafenib use within the Cancer Drugs Fund and not for routine use
  • 07 Oct 2016 Efficacy data from a phase III trial in Thyroid cancer presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
  • 07 Oct 2016 Efficacy, adverse events and pharmacokinetics data from a phase I trial in Breast cancer presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
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