Drug Profile


Alternative Names: AMG-951; PRO 1762; Recombinant human Apo2L/TRAIL; RG 3639; Rh-Apo2L - Amgen/Genentech; rhApo2L/TRAIL; TNF-related apoptosis-inducing ligand; TRAIL/Apo2L

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Amgen
  • Developer Amgen; Genentech
  • Class Antineoplastics; Recombinant proteins
  • Mechanism of Action Apoptosis stimulants; TRAIL receptor 1 agonists; TRAIL receptor 2 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Colorectal cancer; Non-Hodgkin's lymphoma; Non-small cell lung cancer

Most Recent Events

  • 17 Apr 2016 Biomarkers information updated
  • 26 Jul 2011 Discontinued - Phase-I for Colorectal cancer in USA (IV)
  • 15 Jun 2011 Genentech and Amgen terminate a phase I/II trial in Non-Hodgkin's lymphoma in Australia, European Union, New Zealand and USA(NCT00400764)
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