Drug Profile


Alternative Names: B-1287; E-5564; Eritoran tetrasodium

Latest Information Update: 06 Oct 2017

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At a glance

  • Originator Eisai Co Ltd
  • Class Disaccharides; Sugar phosphates
  • Mechanism of Action Endotoxin inhibitors; Lipid A inhibitors; Toll-like receptor 4 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Reperfusion injury; Septic shock

Most Recent Events

  • 22 Dec 2009 Final efficacy and adverse events data from a Phase-II trial in Sepsis released by Eisai
  • 15 Sep 2009 Pharmacodynamics data from a preclinical study presented at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC-2009)
  • 18 Jun 2009 Phase-III clinical trials in Septic shock in Asia (IV)
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