Drug Profile


Alternative Names: CI-1027; Gemcabene calcium; PD 0072953; PD 072953

Latest Information Update: 27 Sep 2017

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At a glance

  • Originator Pfizer
  • Developer Gemphire Therapeutics; Pfizer
  • Class Antihyperlipidaemics; Caproates; Small molecules
  • Mechanism of Action Acetyl-CoA carboxylase inhibitors; Lipoprotein A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypercholesterolaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hypercholesterolaemia; Hyperlipoproteinaemias; Hypertension; Hypertriglyceridaemia; Osteoarthritis
  • Preclinical Non-alcoholic steatohepatitis

Most Recent Events

  • 25 Sep 2017 Additional efficacy and adverse events data from the phase IIb COBALT trial in Hypercholesterolaemia released by Gemphire Therapeutics
  • 19 Sep 2017 Efficacy data from combined analysis of data from phase II trial released by Gemphire Therapeutics
  • 19 Sep 2017 Gemphire plans a phase III trial in Hypercholseterolaemia in 2018
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