Gemcabene - Gemphire Therapeutics

Drug Profile

Gemcabene - Gemphire Therapeutics

Alternative Names: CI-1027; Gemcabene calcium; PD 0072953; PD 072953

Latest Information Update: 19 Jan 2018

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At a glance

  • Originator Pfizer
  • Developer Gemphire Therapeutics; Pfizer
  • Class Antihyperlipidaemics; Caproates; Small molecules
  • Mechanism of Action Acetyl-CoA carboxylase inhibitors; Apolipoprotein C-III inhibitors; C-reactive protein inhibitors; CCR2 receptor antagonists; CCR5 receptor antagonists; Lipoprotein A inhibitors; Sulfatase inhibitors; VLDL receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypercholesterolaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hypercholesterolaemia; Hyperlipoproteinaemias; Hypertension; Hypertriglyceridaemia; Non-alcoholic steatohepatitis; Osteoarthritis

Most Recent Events

  • 17 Jan 2018 Gemphire completes enrolment in the phase IIb INDIGO-1 trial for Hypertriglyceridemia in USA and Canada (NCT02944383)
  • 21 Dec 2017 Phase-II clinical trials in Non-alcoholic steatohepatitis in USA (PO)
  • 21 Dec 2017 Gemphire Therapeutics has an open Investigational New Drug application for Non-alcoholic steatohepatitis
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