Drug Profile


Alternative Names: EDP-103; KHK-2375; MS-27-275; MS-275; SNDX-275

Latest Information Update: 09 Oct 2017

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At a glance

  • Originator Nihon Schering; Pfizer; University of Tokyo
  • Developer Eddingpharm; Genentech; Kyowa Hakko Kirin; Memorial Sloan-Kettering Cancer Center; Merck & Co; National Cancer Institute (USA); Pfizer; Roswell Park Cancer Institute; Syndax Pharmaceuticals
  • Class Antineoplastics; Benzamides; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Colorectal cancer; Endometrial cancer; Follicular lymphoma; Hodgkin's disease; Leukaemia; Malignant melanoma; Non-small cell lung cancer
  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Renal cell carcinoma
  • Preclinical Pancreatic cancer

Most Recent Events

  • 06 Oct 2017 Phase-II clinical trials in Endometrial cancer (Neoadjuvant therapy) in USA (PO) (NCT03018249)
  • 22 Sep 2017 Phase-II clinical trials in Breast cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in Japan (PO) (JapicCTI-173703; NCT03291886)
  • 19 Sep 2017 Kyowa Hakko Kirin plans a phase II trial for Breast cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in Japan
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