Entinostat

Drug Profile

Entinostat

Alternative Names: EDP-103; KHK-2375; MS-27-275; MS-275; SNDX-275

Latest Information Update: 06 Mar 2017

Price : $50

At a glance

  • Originator Nihon Schering; Pfizer; University of Tokyo
  • Developer Eddingpharm; Genentech; Kyowa Hakko Kirin; Merck & Co; National Cancer Institute (USA); Pfizer; Roswell Park Cancer Institute; Syndax Pharmaceuticals
  • Class Antineoplastics; Benzamides; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Hodgkin's disease; Leukaemia; Non-small cell lung cancer
  • Phase I/II Fallopian tube cancer; Malignant melanoma; Ovarian cancer; Peritoneal cancer; Renal cell carcinoma
  • Phase Unknown Endometrial cancer
  • No development reported Colorectal cancer

Most Recent Events

  • 02 Mar 2017 Syndax completes enrolment in the phase II portion of the ENCORE 602 trial for Breast cancer (Combination therapy, Locally recurrent, Metastatic disease, Second-line therapy or greater) in USA
  • 02 Mar 2017 Syndax initiates enrolment in the phase II portion of the ENCORE 601 trial for Non-small cell lung cancer or Melanoma (Combination therapy) in USA
  • 09 Feb 2017 Phase-I/II clinical trials in Fallopian tube cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (PO) (9211371; Syndax Pharmaceuticals pipeline, February 2017)
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