Entinostat - Syndax Pharmaceuticals

Drug Profile

Entinostat - Syndax Pharmaceuticals

Alternative Names: EDP-103; Entinostat; KHK-2375; MS-27-275; MS-275; SNDX-275

Latest Information Update: 16 Nov 2017

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At a glance

  • Originator Nihon Schering; Pfizer; University of Tokyo
  • Developer Eddingpharm; Genentech; Kyowa Hakko Kirin; Memorial Sloan-Kettering Cancer Center; Merck & Co; National Cancer Institute (USA); Pfizer; Roswell Park Cancer Institute; Syndax Pharmaceuticals
  • Class Antineoplastics; Benzamides; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Colorectal cancer; Endometrial cancer; Follicular lymphoma; Hodgkin's disease; Leukaemia; Malignant melanoma; Non-small cell lung cancer
  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Renal cell carcinoma
  • Preclinical Pancreatic cancer

Most Recent Events

  • 05 Dec 2017 UNC Lineberger Comprehensive Cancer Center, Syndax Pharmaceuticals and National Cancer Institute plan an early phase I trial (window of opportunity trial) for HR+ or triple negative Breast cancer (Newly-diagnosed, First-line therapy) in USA (PO, Tablet) (NCT03361800)
  • 11 Nov 2017 Syndax Pharmaceuticals intends to define regulatory path for entinostat for Malignant melanoma (Combination therapy) in the first half of 2018
  • 11 Nov 2017 Updated efficacy data from the phase II ENCORE 601 trial in Non-small cell lung cancer, Malignant melanoma and Colorectal cancer released by Syndax Pharmaceuticals
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