Lenalidomide

Drug Profile

Lenalidomide

Alternative Names: CC-5013; CDC-501; CDC-5013; ENMD-0997; IMiD-1; IMiD-3; Ladevina; Revimid™; Revlimid

Latest Information Update: 18 Sep 2017

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At a glance

  • Originator Celgene Corporation
  • Developer Baylor College of Medicine; Celgene Corporation; Dana-Farber Cancer Institute; H. Lee Moffitt Cancer Center and Research Institute; Indiana University School of Medicine; IRCCS San Raffaele; Massachusetts General Hospital; National Cancer Institute (USA); Novartis; Ohio State University Comprehensive Cancer Center; Peking Union Medical College Hospital; Roche; Roswell Park Cancer Institute; SCRI Development Innovations; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Florida; University of Wuerzburg; Washington University School of Medicine
  • Class 2 ring heterocyclic compounds; Antineoplastics; Imides; Isoindoles; Piperidones; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Immunomodulators; Interleukin 1 beta inhibitors; Interleukin 10 stimulants; Interleukin 2 receptor modulators; Tumour necrosis factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma; Myelodysplastic syndromes; Chronic lymphocytic leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Mantle-cell lymphoma; Multiple myeloma; Myelodysplastic syndromes
  • Preregistration Adult T-cell leukaemia-lymphoma
  • Phase III Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Non-Hodgkin's lymphoma
  • Phase II Acute myeloid leukaemia; Histiocytosis; Hodgkin's disease; POEMS syndrome
  • Phase I/II Non-small cell lung cancer
  • Phase I Cancer; Chronic myeloid leukaemia; Peripheral T-cell lymphoma
  • No development reported Eye neoplasms; Glioblastoma; Myelofibrosis; Prostate cancer
  • Discontinued Colorectal cancer; Heart failure; Hepatocellular carcinoma; Inflammation; Malignant melanoma

Most Recent Events

  • 14 Sep 2017 Oncolytics Biotech, Celgene Corporation and University of Leeds initiate enrolment in the phase I MUK eleven trial in Multiple myeloma (Combination therapy, Second-line therapy or greater) in United Kingdom (IV) (ISRCTN14749537)
  • 31 Aug 2017 Lenalidomide market licensed to BeiGene in China
  • 15 Aug 2017 Celgene terminates a phase I trial in Acute myeloid leukaemia (Combination therapy, Second-line therapy or greater) due to slow accrual in USA (PO) (NCT02255162)
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