MDCO 216

Drug Profile

MDCO 216

Alternative Names: AIM; ApoA1 Milano; ESP-24217; ET-216; ETC-216; MDCO-216; r-ApoA-I Milano; rApoA-IM; rApoA-IM protein (dimer)

Latest Information Update: 30 Nov 2016

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At a glance

  • Originator Pfizer
  • Developer Esperion Therapeutics; The Medicines Company
  • Class Ischaemic heart disorder therapies; Phosphatidylcholines; Phospholipids
  • Mechanism of Action Apolipoprotein A I stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute coronary syndromes; Coronary artery disease; Coronary artery restenosis

Most Recent Events

  • 07 Nov 2016 Discontinued - Phase-I for Coronary artery disease in USA due to lack of effficacy (IV)
  • 07 Nov 2016 Discontinued - Phase-II for Acute coronary syndromes in Canada, Czech Republic, Netherlands, Poland, Hungary and USA due to lack of effficacy (IV)
  • 26 Oct 2016 The Medicines Company initiates the phase II MILANO DRIVE trial for Acute coronary syndromes in Hungary (IV, Infusion) (EudraCT2014-005462-30)
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