Ticagrelor

Drug Profile

Ticagrelor

Alternative Names: AR-C 126532; AZD-6140; Brilinta; Brilique

Latest Information Update: 23 Dec 2016

Price : $50

At a glance

  • Originator AstraZeneca
  • Developer AstraZeneca; The Medicines Company; Uppsala University; Vanderbilt University
  • Class Antithrombotics; Cyclopropanes; Fluorobenzenes; Purine nucleosides; Ribonucleosides; Small molecules
  • Mechanism of Action Platelet ADP receptor antagonists; Purinoceptor P2Y12 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute coronary syndromes
  • Phase III Cardiovascular disorders; Stroke
  • Phase II Abdominal aortic aneurysm; Community-acquired pneumonia; Coronary artery disease; Sickle cell anaemia
  • Discontinued Peripheral arterial disorders

Most Recent Events

  • 01 Nov 2016 AstraZeneca completes the Hestia2 trial in Sickle cell anaemia (In adults) in USA, Egypt, France, Italy, Kenya, Lebanon, Turkey and United Kingdom (NCT02482298)
  • 30 Sep 2016 Discontinued - Phase-III for Peripheral arterial disorders in Sweden, Germany, Poland, Poland, Netherlands, United Kingdom, Hungary, Spain, Czech Republic, Bulgaria, France, Argentina, Brazil, Canada, Chile, China, Japan, Vietnam, Ukraine, Thailand, Turkey, Slovakia, Russia, Philippines, Mexico, South Korea, USA, Italy, Romania (PO) before September 2016 as the trial did not meet its primary endpoint (AstraZeneca pipeline, November 2016; AstraZeneca Third quarter results, November 2016)
  • 30 Sep 2016 Registered for Acute coronary syndromes in Japan (PO) before September 2016 (AstraZeneca pipeline, November 2016; AstraZeneca Third quarter results, November 2016)
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