Research programme: antibacterials - Microbiotix

Drug Profile

Research programme: antibacterials - Microbiotix

Alternative Names: 259C; AcrAB-TolC efflux pump inhibitors - Microbiotix; Aminospectinomycins - Microbiotix; AU-FQ hybrids; bIAI compounds; bis-imidazolinylindole compound series; Fatty acid biosynthesis (FAB) pathway inhibitors - Microbiotix; Inhibitors of DnaA initiator protein - Microbiotix; Inhibitors of initiation of DNA replication - Microbiotix; Inhibitors of wall teichoic acid (WTA) - Microbiotix; MBX 1158; MBX 1162; MBX 1196; MBX 1337; MBX 1339; MBX 1641; MBX 2319 analogues - Microbiotix; MBX 3132; MBX 3795; MBX 3796; MBX 3797; MBX-500; Sortase A (SrtA) inhibitors for Gram-positive infections - Microbiotix; SOS induction inhibitors - Microbiotix; Spectinamide antibacterials for MDR/XDR tuberculosis - Microbiotix; Spectinomycin analogues - Microbiotix; T3SS inhibitors; TTSS inhibitors; Tuberculosis therapies - Microbiotix

Latest Information Update: 21 Sep 2016

Price : $50

At a glance

  • Originator Microbiotix
  • Developer GLSynthesis; Microbiotix
  • Class Acetamides; Amidines; Aminocyclitols; Carboxylic acids; Coumarins; Heterocyclic compounds; Imidazoles; Indoles; Pyrazoles; Small molecules
  • Mechanism of Action DNA gyrase inhibitors; DNA helicase inhibitors; DNA helicase-primase inhibitors; DNA synthesis inhibitors; DNA-binding protein inhibitors; DNA-directed DNA polymerase inhibitors; Lipoteichoic acid inhibitors; Membrane protein inhibitors; Sortase A inhibitors; Toll-like receptor 5 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Bacterial infections; Gram-negative infections
  • Research Gram-positive infections; Methicillin-resistant Staphylococcus aureus infections; Pseudomonal infections; Tuberculosis

Most Recent Events

  • 16 Jun 2016 Data from preclinical studies in Multidrug-resistant (MDR) Gram-negative infections presented at 56th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC-2016) (3199902; 3199911)
  • 01 Jun 2016 Preclinical trials in Gram-negative infections in USA (IV) before June 2016
  • 03 Apr 2012 Preclinical development is ongoing in US
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