Drug Profile


Alternative Names: CF-102; Cl-IB-MECA

Latest Information Update: 11 Aug 2017

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At a glance

  • Originator National Institutes of Health (USA)
  • Developer Can-Fite BioPharma; Rabin Medical Center; Temple University School of Medicine
  • Class Amides; Anti-inflammatories; Antineoplastics; Antivirals; Iodobenzenes; Purine nucleosides; Small molecules
  • Mechanism of Action Adenosine A3 receptor agonists; Hepatitis C virus NS 5 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatocellular carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hepatocellular carcinoma
  • Preclinical Colorectal cancer; Hepatic fibrosis; Malignant melanoma; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Prostate cancer; Reperfusion injury
  • Discontinued Hepatitis B; Hepatitis C

Most Recent Events

  • 09 Aug 2017 Can-Fite BioPharma completes enrolment in its phase II trial for Hepatocellular carcinoma (Refractory metastatic disease, Second-line therapy or greater, Late-stage disease) in USA, Europe and Israel
  • 02 Jun 2017 Preclinical trials in Hepatic fibrosis in Israel (unspecified route)
  • 02 Jun 2017 Pharmacodynamics data in NASH models released by Can-Fite
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