Aflibercept

Drug Profile

Aflibercept

Alternative Names: AVE-0005; BAY-865321; Eylea; Eylia; VEGF Trap (R1R2); VEGF Trap-Eye; Zaltrap; Ziv-aflibercept

Latest Information Update: 12 Oct 2017

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At a glance

  • Originator Regeneron Pharmaceuticals
  • Developer Bayer HealthCare Pharmaceuticals; Bayer Yakuhin; Centre Oscar Lambret; GERCOR; Guys Hospital; Moorfields Eye Hospital; National Cancer Institute (USA); Regeneron Pharmaceuticals; Sanofi; sanofi-aventis; University of Ulm
  • Class Antineoplastics; Eye disorder therapies; Recombinant fusion proteins
  • Mechanism of Action Placenta growth factor inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Branch retinal vein occlusion; Central retinal vein occlusion; Choroidal neovascularisation; Colorectal cancer; Diabetic macular oedema; Wet age-related macular degeneration
  • Registered Diabetic retinopathy
  • Phase III Glaucoma
  • Phase II Central serous chorioretinopathy
  • Phase I Non-Hodgkin's lymphoma; Solid tumours
  • No development reported Malignant ascites; Ovarian cancer
  • Discontinued Non-small cell lung cancer; Pancreatic cancer; Prostate cancer

Most Recent Events

  • 31 Aug 2017 Pharmacodynamics data from a preclinical trial in Colorectal cancer presented at the 42nd European Society for Medical Oncology Congress (ESMO-2017)
  • 03 Aug 2017 Regeneron Pharmaceuticals announces intention to apply for regulatory approvals for Atopic dermatitis outside USA in 2017
  • 03 Aug 2017 Regeneron Pharmaceuticals announces intention to submit sBLA to US FDA for Wet age-related macular degeneration in 2017 (12-weekly dosing)
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