Aflibercept

Drug Profile

Aflibercept

Alternative Names: AVE-0005; BAY-865321; Eylea; Eylia; VEGF Trap (R1R2); VEGF Trap-Eye; Zaltrap; Ziv-aflibercept

Latest Information Update: 26 Dec 2016

Price : $50

At a glance

  • Originator Regeneron Pharmaceuticals
  • Developer Bayer HealthCare Pharmaceuticals; Bayer Yakuhin; Centre Oscar Lambret; GERCOR; Guys Hospital; Moorfields Eye Hospital; National Cancer Institute (USA); Regeneron Pharmaceuticals; Sanofi; sanofi-aventis; University of Ulm
  • Class Antineoplastics; Eye disorder therapies; Recombinant fusion proteins
  • Mechanism of Action Placenta growth factor inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Branch retinal vein occlusion; Central retinal vein occlusion; Choroidal neovascularisation; Colorectal cancer; Diabetic macular oedema; Wet age-related macular degeneration
  • Registered Diabetic retinopathy
  • Phase III Glaucoma
  • Phase II Central serous chorioretinopathy
  • Phase I Non-Hodgkin's lymphoma; Solid tumours
  • No development reported Malignant ascites; Ovarian cancer
  • Discontinued Non-small cell lung cancer; Pancreatic cancer; Prostate cancer

Most Recent Events

  • 02 Dec 2016 Bayer Yakuhin terminates enrolment phase III trial in Choroidal neovascularisation in Japan (UMIN000012493)
  • 01 Nov 2016 Bayer initiates the phase IIIb VIOLET trial for Diabetic macular oedema in Czech Republic, Italy and United Kingdom (Intravitreal) (NCT02818998)
  • 01 Sep 2016 Bayer completes a phase III trial in Glaucoma in Japan (NCT02396316)
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