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Trastuzumab emtansine - Immunogen/Roche

Drug Profile

Trastuzumab emtansine - Immunogen/Roche

Alternative Names: Ado-trastuzumab emtansine; DM1-trastuzumab immunoconjugate; Herceptin-DM1; Kadcyla; PRO-132365; R3502; RG 3502; RG3502-10; RO 5304020; T-DM1; Trastuzumab-DM1; Trastuzumab-DM1 immunoconjugate; Trastuzumab-MCC-DM1; Trastuzumab-MCC-DM1 antibody-drug conjugate; Trastuzumab–SMCC–DM1 conjugate

Latest Information Update: 26 Mar 2024

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At a glance

  • Originator Genentech; ImmunoGen
  • Developer Chugai Pharmaceutical; Dana-Farber Cancer Institute; Genentech; Memorial Sloan-Kettering Cancer Center; Roche; University College London
  • Class Antineoplastics; Drug conjugates; Immunotoxins; Macrolides; Maytansinoids; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer
  • Phase II/III Gastric cancer
  • Phase II Bladder cancer; Lung cancer; Non-small cell lung cancer; Salivary gland cancer; Solid tumours; Urogenital cancer

Most Recent Events

  • 27 Feb 2024 Genentech completes a phase II trial in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease) in USA (PO) (NCT04632992)
  • 12 Feb 2024 ImmunoGen has been acquired by AbbVie
  • 08 Dec 2023 Efficacy and adverse events data from the phase III KATHERINE trial in Breast cancer released by Genentech
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