Drug Profile


Alternative Names: 1766; HMR 1766

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator sanofi-aventis
  • Developer Mayo Clinic; National Center for Advancing Translational Sciences; Sanofi; sanofi-aventis
  • Class Anthranilic acids; Benzamides; Cardiovascular therapies; Chlorobenzenes; Morpholines; Small molecules; Sulfonamides; Thiophenes
  • Mechanism of Action Guanylate cyclase stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Aortic valve stenosis
  • Discontinued Heart failure; Neuropathic pain; Peripheral arterial occlusive disorders

Most Recent Events

  • 30 Jun 2015 Mayo Clinic plans a phase II trial for Aortic valve stenosis in USA (NCT02481258)
  • 31 Mar 2015 Mayo Clinic completes a phase I clinical trial in Aortic valve stenosis in USA (PO) (NCT02049203)
  • 29 Jan 2014 Phase-I clinical trials in Aortic valve stenosis in USA (PO)
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