Pegargiminase

Drug Profile

Pegargiminase

Alternative Names: ADI-PEG; ADI-PEG 20; ADI-SS PEG; Arginine deiminase-PEG; Hepacid; Melanocid; PEG arginine deiminase; Peglyated arginine deiminase - Phoenix Pharmacologics; Pegylated arginine deiminase - Polaris Group

Latest Information Update: 09 Feb 2017

Price : $50

At a glance

  • Originator Phoenix Pharmacologics
  • Developer Barts and The London School of Medicine and Dentistry; Polaris Pharmaceuticals; University of Miami
  • Class Antineoplastics; Hydrolases; Polyethylene glycols; Proteins; Radiosensitisers
  • Mechanism of Action Arginine deiminase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma; Hepatocellular carcinoma; Malignant melanoma
  • New Molecular Entity No

Highest Development Phases

  • Phase III Hepatocellular carcinoma
  • Phase II/III Mesothelioma
  • Phase II Acute myeloid leukaemia; Malignant melanoma; Non-Hodgkin's lymphoma; Small cell lung cancer
  • Phase I Breast cancer; Cancer; Gastrointestinal cancer; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Solid tumours
  • Preclinical Bladder cancer; Glioblastoma; Lymphoma; Renal cell carcinoma; Sarcoma; Viral infections

Most Recent Events

  • 21 Oct 2016 Pharmacodynamics data from a preclinical study in Cancer released by Polaris
  • 01 Sep 2016 Phase-I clinical trials in Acute myeloid leukaemia (Combination therapy, In adolescents, In adults, In the elderly, Recurrent) in Taiwan (Parenteral) (NCT02875093)
  • 01 Sep 2016 Phase-II/III clinical trials in Mesothelioma (Combination therapy, Late-stage disease, First-line therapy) in USA (IM) (NCT02709512)
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