Drug Profile


Alternative Names: ADI; ADI-PEG; ADI-PEG 20; ADI-SS PEG; Arginine deiminase pegylated; Arginine deiminase-PEG; Hepacid; Melanocid; PEG arginine deiminase; Peglyated arginine deiminase - Phoenix Pharmacologics; Pegylated arginine deiminase - Polaris Group

Latest Information Update: 14 Jun 2017

Price : $50

At a glance

  • Originator Phoenix Pharmacologics
  • Developer Barts and The London School of Medicine and Dentistry; Polaris Pharmaceuticals; University of Miami
  • Class Antineoplastics; Hydrolases; Polyethylene glycols; Proteins; Radiosensitisers
  • Mechanism of Action Arginine deiminase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma; Hepatocellular carcinoma; Malignant melanoma
  • New Molecular Entity No

Highest Development Phases

  • Phase III Hepatocellular carcinoma
  • Phase II/III Mesothelioma
  • Phase II Acute myeloid leukaemia; Malignant melanoma; Non-Hodgkin's lymphoma; Small cell lung cancer
  • Phase I Breast cancer; Cancer; Gastrointestinal cancer; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Solid tumours
  • Preclinical Bladder cancer; Glioblastoma; Lymphoma; Renal cell carcinoma; Sarcoma; Viral infections

Most Recent Events

  • 10 May 2017 Polaris terminates a phase II trial for Small cell lung cancer (Second-line therapy or greater) in USA, Belgium, Germany, Taiwan and United Kingdom due to lack of efficacy in Cohort 2 and slow enrolment in Cohort 1 (IM) (NCT01266018)
  • 15 Dec 2016 Biomarkers information updated
  • 21 Oct 2016 Pharmacodynamics data from a preclinical study in Cancer released by Polaris
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