Pegargiminase

Drug Profile

Pegargiminase

Alternative Names: ADI; ADI-PEG; ADI-PEG 20; ADI-SS PEG; Arginine deiminase pegylated; Arginine deiminase-PEG; Hepacid; Melanocid; PEG arginine deiminase; Peglyated arginine deiminase - Phoenix Pharmacologics; Pegylated arginine deiminase - Polaris Group

Latest Information Update: 28 Dec 2017

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At a glance

  • Originator Phoenix Pharmacologics
  • Developer Barts and The London School of Medicine and Dentistry; Polaris Pharmaceuticals; University of Miami
  • Class Antineoplastics; Hydrolases; Polyethylene glycols; Proteins; Radiosensitisers
  • Mechanism of Action Arginine deiminase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma; Hepatocellular carcinoma; Malignant melanoma
  • New Molecular Entity No

Highest Development Phases

  • Phase III Hepatocellular carcinoma
  • Phase II/III Mesothelioma
  • Phase II Acute myeloid leukaemia; Malignant melanoma; Non-Hodgkin's lymphoma; Small cell lung cancer
  • Phase I Solid tumours
  • No development reported Bladder cancer; Breast cancer; Cancer; Gastrointestinal cancer; Glioblastoma; Lymphoma; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Renal cell carcinoma; Sarcoma; Viral infections

Most Recent Events

  • 28 Dec 2017 No recent reports of development identified for phase-I development in Gastrointestinal-cancer(Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (Parenteral)
  • 28 Dec 2017 No recent reports of development identified for phase-I development in Hepatocellular carcinoma(Combination therapy, First-line therapy, Late-stage disease) in USA (IM, Injection)
  • 28 Dec 2017 No recent reports of development identified for phase-I development in Pancreatic-cancer(Combination therapy, First-line therapy, Late-stage disease) in USA (IM, Injection)
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