Drug Profile


Alternative Names: Arcalyst; IL-1 Trap; IL-1 Trap - Regeneron; Interleukin-1 antagonist - Regeneron; Interleukin-1 Trap - Regeneron; RGN 303

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Regeneron Pharmaceuticals
  • Class Anti-inflammatories; Antirheumatics; Recombinant fusion proteins
  • Mechanism of Action Caspase 1 inhibitors; Interleukin 1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cryopyrin-associated periodic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cryopyrin-associated periodic syndromes
  • Discontinued Anaemia; Cardiovascular disorders; Gout; Juvenile rheumatoid arthritis; Osteoarthritis; Polymyalgia rheumatica; Rheumatoid arthritis

Most Recent Events

  • 27 Mar 2015 Regeneron has patent protection for rilonacept in USA
  • 23 Oct 2013 Biomarkers information updated
  • 12 Nov 2012 Regeneron Pharmaceuticals terminates the phase III UPSURGE trial in Gout in USA (NCT01459796)
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