Drug Profile


Alternative Names: LE-AON; LE-rafAON; LErafAON-ETU; Liposomal encapsulated antisense oligonucleotide c-raf-1

Latest Information Update: 18 Oct 2016

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At a glance

  • Originator Georgetown University
  • Developer INSYS Therapeutics, Inc
  • Class Antineoplastics; Antisense oligonucleotides
  • Mechanism of Action Antisense RNA inhibitors; Proto oncogene proteins c raf inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Solid tumours

Most Recent Events

  • 18 Oct 2016 Discontinued - Preclinical for Solid tumours in USA (IV)
  • 05 Mar 2009 Preclinical development is ongoing in USA
  • 31 Dec 2006 Discontinued - Phase-I for Solid tumours in USA (IV)
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