Drug Profile


Alternative Names: ADH-1; ADH-100001; Exherin

Latest Information Update: 23 Feb 2011

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At a glance

  • Originator McGill University
  • Developer Adherex Technologies
  • Class Antineoplastics; Cyclic peptides; Oligopeptides
  • Mechanism of Action Angiogenesis inhibitors; Cadherin modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Malignant melanoma; Solid tumours

Most Recent Events

  • 22 Apr 2009 Preclinical drug interactions data presented at the 100th Annual Meeting of the American Association for Cancer Research (AACR-2009)
  • 02 Jun 2008 Interim efficacy data from a phase I trial in Malignant melanoma released by Adherex Technologies
  • 19 May 2008 Interim efficacy data from a phase I/II trial in malignant melanoma released by Adherex
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