Drug Profile


Alternative Names: JTT-705; R 1658; RG1658; RO 4607381

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Japan Tobacco
  • Developer DalCor Pharmaceuticals; Japan Tobacco; Montreal Heart Institute; Roche
  • Class Antihyperlipidaemics; Cyclohexanes; Small molecules; Thioesters
  • Mechanism of Action Cholesterol ester transfer protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute coronary syndromes
  • Discontinued Atherosclerosis; Coronary disorders; Hyperlipidaemia

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 18 Jul 2016 Pharmacodynamics data from the phase III dal-OUTCOMES trial in Acute coronary syndromes released by DalCor Pharmaceuticals
  • 26 Apr 2016 Phase-III clinical trials in Acute coronary syndromes in Canada (PO) (NCT02525939)
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